InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mttp

Summary

InnateDB Protein

IDBP-196209.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mttp

Protein Name

microsomal triglyceride transfer protein

Synonyms

1810043K16Rik; MTP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029805

InnateDB Gene

IDBG-196207 (Mttp)

Protein Structure

UniProt Annotation

Function

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins. Loads phospholipid into the C1D1 antigen-binding groove. Isoform 2 is critical for the development of natural killer T (NKT) cells. May have a role in the biogenesis of lipid droplets. {ECO:0000269PubMed:17312007, ECO:0000269PubMed:17635917, ECO:0000269PubMed:18502767}.

Subcellular Localization

Isoform 1: Endoplasmic reticulum. Note=Localized to the endoplasmic reticulum according to PubMed:17312007.Isoform 2: Endoplasmic reticulum. Golgi apparatus. Note=Localized to the endoplasmic reticulum according to PubMed:17312007. Localized to the Golgi apparatus according to PubMed:17635917.

Disease Associations

Tissue Specificity

Expressed in heart. Isoform 1 is mainly expressed in the intestine and the liver, and at lower levels in white and brown fat cells. Isoform 2 is ubiquitous, and is the major isoform in hematopoietic cells and adipocytes. {ECO:0000269PubMed:17312007, ECO:0000269PubMed:17635917, ECO:0000269PubMed:9502759}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0034185	apolipoprotein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006497	protein lipidation
GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006869	lipid transport
GO:0008203	cholesterol metabolic process
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0042953	lipoprotein transport
GO:0051592	response to calcium ion

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016323	basolateral plasma membrane
GO:0031526	brush border membrane
GO:0031528	microvillus membrane
GO:0031988	membrane-bounded vesicle
GO:0043235	receptor complex