InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NMU

Summary

InnateDB Protein

IDBP-19642.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NMU

Protein Name

neuromedin U

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264218

InnateDB Gene

IDBG-19638 (NMU)

Protein Structure

UniProt Annotation

Function

Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed throughout the enteric nervous system with highest levels being found in the jejunum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0042922	neuromedin U receptor binding

Biological Process

GO:0001696	gastric acid secretion
GO:0006940	regulation of smooth muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007586	digestion
GO:0009648	photoperiodism
GO:0019233	sensory perception of pain
GO:0042755	eating behavior
GO:0045987	positive regulation of smooth muscle contraction
GO:0046887	positive regulation of hormone secretion
GO:0050806	positive regulation of synaptic transmission