InnateDB Protein
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IDBP-19661.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HDAC11
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Protein Name
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histone deacetylase 11
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000295757
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InnateDB Gene
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IDBG-19657 (HDAC11)
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Protein Structure
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Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. {ECO:0000269PubMed:11948178}.
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Subcellular Localization |
Nucleus. Note=Predominantly nuclear.
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Disease Associations |
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Tissue Specificity |
Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
137
[view]
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Protein-Protein |
135
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
1
[view]
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004407
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histone deacetylase activity
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GO:0005515
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protein binding
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GO:0008134
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transcription factor binding
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GO:0016787
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hydrolase activity
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GO:0032041
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NAD-dependent histone deacetylase activity (H3-K14 specific)
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GO:0046969
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NAD-dependent histone deacetylase activity (H3-K9 specific)
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GO:0046970
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NAD-dependent histone deacetylase activity (H4-K16 specific)
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GO:0097372
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NAD-dependent histone deacetylase activity (H3-K18 specific)
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000286
Histone deacetylase superfamily
IPR023801
Histone deacetylase domain
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PFAM |
PF00850
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PRINTS |
PR01270
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96DB2
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PhosphoSite |
PhosphoSite-Q96DB2
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TrEMBL |
Q6IA14
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UniProt Splice Variant |
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Entrez Gene |
79885
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UniGene |
Hs.620910
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RefSeq |
NP_079103
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HUGO |
HGNC:19086
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OMIM |
607226
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CCDS |
CCDS2615
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HPRD |
09146
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IMGT |
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EMBL |
AC027124
AK025426
AK025890
AK293223
AL137362
BC009676
CH471055
CR457341
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GenPept |
AAH09676
BAB15127
BAB15272
BAG56762
CAB70712
CAG33622
EAW64165
EAW64168
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