InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KAT6A

Summary

InnateDB Protein

IDBP-19710.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KAT6A

Protein Name

K(lysine) acetyltransferase 6A

Synonyms

MOZ; MYST3; RUNXBP2; ZC2HC6A; ZNF220;

Species

Homo sapiens

Ensembl Protein

ENSP00000265713

InnateDB Gene

IDBG-19708 (KAT6A)

Protein Structure

UniProt Annotation

Function

Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269PubMed:11742995, ECO:0000269PubMed:11965546, ECO:0000269PubMed:12771199, ECO:0000269PubMed:16387653, ECO:0000269PubMed:17925393, ECO:0000269PubMed:23431171}.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, PML body. Note=Recruited into PML body after DNA damage.

Disease Associations

Note=Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A- CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.Note=A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	6 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016407	acetyltransferase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0006323	DNA packaging
GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006473	protein acetylation
GO:0016573	histone acetylation
GO:0030099	myeloid cell differentiation
GO:0043966	histone H3 acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0090398	cellular senescence

Cellular Component

GO:0000786	nucleosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005794	Golgi apparatus
GO:0016605	PML body
GO:0070776	MOZ/MORF histone acetyltransferase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001965 Zinc finger, PHD-type
IPR002717 MOZ/SAS-like protein
IPR005818 Linker histone H1/H5, domain H15
IPR011011 Zinc finger, FYVE/PHD-type
IPR016181 Acyl-CoA N-acyltransferase
IPR019787 Zinc finger, PHD-finger

PFAM

PF01853
PF00538
PF00628

PRINTS

PIRSF

SMART

SM00249
SM00526

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92794