InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ehd3

Summary

InnateDB Protein

IDBP-197452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ehd3

Protein Name

EH-domain containing 3

Synonyms

Ehd2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024860

InnateDB Gene

IDBG-197450 (Ehd3)

Protein Structure

UniProt Annotation

Function

Plays a role in endocytic transport. {ECO:0000250}.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm.

Disease Associations

Tissue Specificity

Strong expression seen in the kidney, brain and liver. In the kidney, expressed exclusively by glomerular endothelial cells. {ECO:0000269PubMed:17251388}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0032456	endocytic recycling
GO:0051260	protein homooligomerization
GO:0072661	protein targeting to plasma membrane
GO:0086036	regulation of cardiac muscle cell membrane potential