InnateDB Protein
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IDBP-197641.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rassf1
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Protein Name
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Ras association (RalGDS/AF-6) domain family member 1
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Synonyms
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123F2; AA536941; AU044980; NORE2A; Rassf1A; Rassf1B; Rassf1C; RDA32; REH3P21;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000010211
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InnateDB Gene
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IDBG-197637 (Rassf1)
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Protein Structure
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Function |
Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage (By similarity). {ECO:0000250}.
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Subcellular Localization |
Isoform A: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus (By similarity). {ECO:0000250}.Isoform C: Nucleus {ECO:0000250}. Note=Predominantly nuclear. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
47 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1928386
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InterPro |
IPR000159
Ras-association
IPR011524
SARAH domain
IPR029071
Ubiquitin-related domain
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PFAM |
PF00788
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PRINTS |
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PIRSF |
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SMART |
SM00314
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TIGRFAMs |
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Modification |
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SwissProt |
Q99MK9
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PhosphoSite |
PhosphoSite-Q99MK9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56289
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UniGene |
Mm.488708
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RefSeq |
NP_062687
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MGI ID |
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MGI Symbol |
Rassf1
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OMIM |
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CCDS |
CCDS23494
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HPRD |
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IMGT |
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EMBL |
AF132851
AF333027
BC002173
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GenPept |
AAD30061
AAH02173
AAK21200
AAK21201
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