InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gdf11

Summary

InnateDB Protein

IDBP-198556.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdf11

Protein Name

growth differentiation factor 11

Synonyms

BMP-11; Bmp11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026408

InnateDB Gene

IDBG-198554 (Gdf11)

Protein Structure

UniProt Annotation

Function

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in the developing limb bud, initially detected in the distal mesenchyme, and later localizing to regions around the developing bones. Is also expressed in adult dental pulp and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001501	skeletal system development
GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0008285	negative regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0021512	spinal cord anterior/posterior patterning
GO:0031016	pancreas development
GO:0040007	growth
GO:0045596	negative regulation of cell differentiation
GO:0048469	cell maturation
GO:0048593	camera-type eye morphogenesis
GO:0060021	palate development