InnateDB Protein
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IDBP-198799.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Casc5
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Protein Name
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cancer susceptibility candidate 5
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Synonyms
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2310043D08Rik; 5730505K17Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000028799
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InnateDB Gene
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IDBG-198797 (Casc5)
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Protein Structure
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Function |
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Directly links spindle checkpoint proteins BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1923714
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q66JQ7
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PhosphoSite |
PhosphoSite-Q66JQ7
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TrEMBL |
A3KGI6
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UniProt Splice Variant |
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Entrez Gene |
76464
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UniGene |
Mm.481433
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RefSeq |
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MGI ID |
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MGI Symbol |
Casc5
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK009772
AK033132
AL772264
BC080815
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GenPept |
AAH80815
BAB26494
BAC28167
CAM45955
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