InnateDB Protein
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IDBP-198877.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rnf34
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Protein Name
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ring finger protein 34
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Synonyms
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AW061037; AW536122; BC004042; C88279; RIFF;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000031434
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InnateDB Gene
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IDBG-198875 (Rnf34)
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Protein Structure
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Function |
Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol 5-phosphate and phosphatidylinositol 3- phosphate (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus speckle {ECO:0000250}. Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
GO:0016567
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protein ubiquitination
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:1902042
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negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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GO:2001271
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negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
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Cellular Component |
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PDB ID |
MGI:2153340
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InterPro |
IPR001841
Zinc finger, RING-type
IPR011011
Zinc finger, FYVE/PHD-type
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PFAM |
PF13639
PF14634
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q99KR6
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PhosphoSite |
PhosphoSite-Q99KR6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80751
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UniGene |
Mm.471993
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RefSeq |
NP_085041
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MGI ID |
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MGI Symbol |
Rnf34
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OMIM |
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CCDS |
CCDS19656
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HPRD |
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IMGT |
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EMBL |
AF434815
AK045696
AK046274
AK046381
AK077221
AK132330
AK137606
AK150976
AK159753
BC004042
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GenPept |
AAH04042
AAL30770
BAC32461
BAC32666
BAC32697
BAC36693
BAE21109
BAE23428
BAE30005
BAE35344
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