InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYT8

Summary

InnateDB Protein

IDBP-19909.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYT8

Protein Name

synaptotagmin VIII

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000371394

InnateDB Gene

IDBG-19905 (SYT8)

Protein Structure

UniProt Annotation

Function

Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0007340

acrosome reaction

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031988	membrane-bounded vesicle