Version 5.4
Mus musculus Protein: Def8
Summary
InnateDB Protein IDBP-199257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Def8
Protein Name differentially expressed in FDCP 8
Synonyms AI449518; D8Ertd713e; DEF-8;
Species Mus musculus
Ensembl Protein ENSMUSP00000001522
InnateDB Gene IDBG-199253 (Def8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity Abundantly expressed in peripheral blood leukocytes. Highly expressed in B-cells. Also present in lymph node and appendix. Down-regulated upon macrophage/granulocyte differentiation. Weakly expressed in bone marrow and spleen. Weakly or not expressed in thymus and fetal liver. {ECO:0000269PubMed:10460589}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:1346331
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
PFAM PF00130
PRINTS
PIRSF
SMART SM00109
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99J78
PhosphoSite PhosphoSite-Q99J78
TrEMBL D5MR38
UniProt Splice Variant
Entrez Gene 23854
UniGene Mm.457304
RefSeq NP_001240713
MGI ID
MGI Symbol Def8
OMIM
CCDS CCDS57647
HPRD
IMGT
EMBL AB504830 AB504831 AB504832 AB504833 AB504834 AB504835 AB504836 AB504837 AB504838 AB504839 AC122266 AK034028 AK050405 AK081295 AK087778 AK133979 AK150334 AK150994 AK164147 BC003306 X96708
GenPept AAH03306 BAC28551 BAC34239 BAC38184 BAC39999 BAE21966 BAE29476 BAE30018 BAE37649 BAJ07159 BAJ07160 BAJ07161 BAJ07162 BAJ07163 BAJ07164 BAJ07165 BAJ07166 BAJ07167 BAJ07168

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca