InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ran

Summary

InnateDB Protein

IDBP-201757.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ran

Protein Name

RAN, member RAS oncogene family

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031383

InnateDB Gene

IDBG-201755 (Ran)

Protein Structure

UniProt Annotation

Function

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18347012}. Cytoplasm {ECO:0000269PubMed:18347012}. Melanosome {ECO:0000250}. Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis.

Disease Associations

Tissue Specificity

Expressed in a variety of tissues, including testis. {ECO:0000269PubMed:7849398}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006606	protein import into nucleus
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030036	actin cytoskeleton organization
GO:0034613	cellular protein localization
GO:0034629	cellular protein complex localization

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0042470	melanosome

Protein Structure and Domains

PDB ID

MGI:1333112

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt