InnateDB Protein
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IDBP-20176.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WARS
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Protein Name
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tryptophanyl-tRNA synthetase
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Synonyms
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GAMMA-2; IFI53; IFP53;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000339485
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InnateDB Gene
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IDBG-20170 (WARS)
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Protein Structure
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Function |
Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. {ECO:0000269PubMed:11773625, ECO:0000269PubMed:11773626, ECO:0000269PubMed:1373391, ECO:0000269PubMed:14630953}.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
42
[view]
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Protein-Protein |
42
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002305
Aminoacyl-tRNA synthetase, class Ic
IPR002306
Tryptophan-tRNA ligase
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PFAM |
PF00579
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PRINTS |
PR01039
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P23381
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PhosphoSite |
PhosphoSite-P23381
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TrEMBL |
G3V5U1
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UniProt Splice Variant |
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Entrez Gene |
7453
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UniGene |
Hs.736264
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RefSeq |
NP_998811
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HUGO |
HGNC:12729
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OMIM |
191050
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CCDS |
CCDS9961
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HPRD |
01845
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IMGT |
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EMBL |
AK056100
AK291141
AL135838
AL157871
BC017489
BC095453
BX248006
CH471061
M61715
M77804
S82905
X59892
X62570
X67920
X67921
X67922
X67923
X67924
X67925
X67926
X67927
X67928
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GenPept |
AAA61298
AAA67324
AAB39381
AAH17489
AAH95453
BAF83830
BAG51626
CAA42545
CAA44450
CAB94198
CAB94199
CAD62335
EAW81700
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