InnateDB Protein
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IDBP-202959.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Lat2
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Protein Name
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linker for activation of T cells family, member 2
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Synonyms
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AW125574; LAB; NTAL; Wbscr15; Wbscr5; WSCR5;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000046900
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InnateDB Gene
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IDBG-202957 (Lat2)
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Protein Structure
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Function |
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269PubMed:15477348, ECO:0000269PubMed:15477350, ECO:0000269PubMed:15899851}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:15477348, ECO:0000269PubMed:15477350}; Single-pass type III membrane protein {ECO:0000269PubMed:15477348, ECO:0000269PubMed:15477350}. Note=Present in lipid rafts.
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Disease Associations |
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Tissue Specificity |
Strongly expressed in testis. Expressed in heart, spleen and lung. Present in B-cells and mast cells (at protein level). {ECO:0000269PubMed:11124535, ECO:0000269PubMed:15477350, ECO:0000269PubMed:15539154}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1926479
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JHL0
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PhosphoSite |
PhosphoSite-Q9JHL0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56743
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UniGene |
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RefSeq |
NP_064428
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MGI ID |
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MGI Symbol |
Lat2
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OMIM |
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CCDS |
CCDS39312
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HPRD |
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IMGT |
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EMBL |
AF139987
AF257136
AF289664
AK134721
AK138953
AK143533
AK162321
AY190024
BC005804
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GenPept |
AAF75558
AAF75559
AAF91353
AAF99331
AAH05804
AAO63156
BAE22256
BAE23833
BAE25422
BAE36852
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