Version 5.4
Mus musculus Protein: Lat2
Summary
InnateDB Protein IDBP-202961.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lat2
Protein Name linker for activation of T cells family, member 2
Synonyms AW125574; LAB; NTAL; Wbscr15; Wbscr5; WSCR5;
Species Mus musculus
Ensembl Protein ENSMUSP00000076824
InnateDB Gene IDBG-202957 (Lat2)
Protein Structure
UniProt Annotation
Function Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269PubMed:15477348, ECO:0000269PubMed:15477350, ECO:0000269PubMed:15899851}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15477348, ECO:0000269PubMed:15477350}; Single-pass type III membrane protein {ECO:0000269PubMed:15477348, ECO:0000269PubMed:15477350}. Note=Present in lipid rafts.
Disease Associations
Tissue Specificity Strongly expressed in testis. Expressed in heart, spleen and lung. Present in B-cells and mast cells (at protein level). {ECO:0000269PubMed:11124535, ECO:0000269PubMed:15477350, ECO:0000269PubMed:15539154}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0042169 SH2 domain binding
Biological Process
GO:0019722 calcium-mediated signaling
GO:0035556 intracellular signal transduction
GO:0042113 B cell activation
GO:0043303 mast cell degranulation
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0042629 mast cell granule
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID MGI:1926479
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JHL0
PhosphoSite PhosphoSite-Q9JHL0
TrEMBL
UniProt Splice Variant
Entrez Gene 56743
UniGene
RefSeq NP_075253
MGI ID
MGI Symbol Lat2
OMIM
CCDS CCDS39311
HPRD
IMGT
EMBL AF139987 AF257136 AF289664 AK134721 AK138953 AK143533 AK162321 AY190024 BC005804
GenPept AAF75558 AAF75559 AAF91353 AAF99331 AAH05804 AAO63156 BAE22256 BAE23833 BAE25422 BAE36852

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca