InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sema6d

Summary

InnateDB Protein

IDBP-203265.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sema6d

Protein Name

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077691

InnateDB Gene

IDBG-203251 (Sema6d)

Protein Structure

UniProt Annotation

Function

Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain and lung. {ECO:0000269PubMed:14715272}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030215	semaphorin receptor binding

Biological Process

GO:0007275	multicellular organismal development
GO:0014911	positive regulation of smooth muscle cell migration
GO:0014912	negative regulation of smooth muscle cell migration
GO:0021591	ventricular system development
GO:0030154	cell differentiation