InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA2

Summary

InnateDB Protein

IDBP-20328.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA2

Protein Name

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

Synonyms

BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000296585

InnateDB Gene

IDBG-20326 (ITGA2)

Protein Structure

UniProt Annotation

Function

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	31 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0032403	protein complex binding
GO:0038064	collagen receptor activity
GO:0043236	laminin binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0002687	positive regulation of leukocyte migration
GO:0006928	cellular component movement
GO:0006929	substrate-dependent cell migration
GO:0006971	hypotonic response
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0009612	response to mechanical stimulus
GO:0009615	response to virus
GO:0009887	organ morphogenesis
GO:0010634	positive regulation of epithelial cell migration
GO:0010694	positive regulation of alkaline phosphatase activity
GO:0014070	response to organic cyclic compound
GO:0014075	response to amine
GO:0014850	response to muscle activity
GO:0014911	positive regulation of smooth muscle cell migration
GO:0016032	viral process
GO:0030198	extracellular matrix organization
GO:0030879	mammary gland development
GO:0031346	positive regulation of cell projection organization
GO:0031589	cell-substrate adhesion
GO:0032870	cellular response to hormone stimulus
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033343	positive regulation of collagen binding
GO:0033591	response to L-ascorbic acid
GO:0033627	cell adhesion mediated by integrin
GO:0038065	collagen-activated signaling pathway
GO:0042060	wound healing
GO:0042493	response to drug
GO:0043388	positive regulation of DNA binding
GO:0043589	skin morphogenesis
GO:0045184	establishment of protein localization
GO:0045727	positive regulation of translation
GO:0045785	positive regulation of cell adhesion
GO:0045987	positive regulation of smooth muscle contraction
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0050927	positive regulation of positive chemotaxis
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0051971	positive regulation of transmission of nerve impulse
GO:0060100	positive regulation of phagocytosis, engulfment
GO:0070365	hepatocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009279	cell outer membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0030424	axon
GO:0042995	cell projection
GO:0043679	axon terminus
GO:0045178	basal part of cell
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2

PFAM

PF00092
PF01839
PF14312
PF08441

PRINTS

PR01185

PIRSF

SMART

SM00327
SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt