InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX47

Summary

InnateDB Protein

IDBP-20405.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX47

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000350698

InnateDB Gene

IDBG-237721 (DDX47)

Protein Structure

UniProt Annotation

Function

Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors. {ECO:0000269PubMed:15977068, ECO:0000269PubMed:16963496}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269PubMed:16963496}. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006364	rRNA processing
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04851
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H0S4