InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndufs2

Summary

InnateDB Protein

IDBP-204244.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufs2

Protein Name

NADH dehydrogenase (ubiquinone) Fe-S protein 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013737

InnateDB Gene

IDBG-204242 (Ndufs2)

Protein Structure

UniProt Annotation

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H
GO:0046872	metal ion binding
GO:0048038	quinone binding
GO:0051287	NAD binding
GO:0051539	4 iron, 4 sulfur cluster binding