InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP2R5C

Summary

InnateDB Protein

IDBP-20539.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2R5C

Protein Name

protein phosphatase 2, regulatory subunit B', gamma

Synonyms

B56G; PR61G;

Species

Homo sapiens

Ensembl Protein

ENSP00000333905

InnateDB Gene

IDBG-20535 (PPP2R5C)

Protein Structure

UniProt Annotation

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. {ECO:0000269PubMed:16456541, ECO:0000269PubMed:17245430}.

Subcellular Localization

Nucleus. Chromosome, centromere.

Disease Associations

Tissue Specificity

Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008601	protein phosphatase type 2A regulator activity

Biological Process

GO:0006508	proteolysis
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0016485	protein processing
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050790	regulation of catalytic activity