InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Errfi1

Summary

InnateDB Protein

IDBP-205857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Errfi1

Protein Name

ERBB receptor feedback inhibitor 1

Synonyms

1300002F13Rik; AI788755; Mig-6; Mig6; RALT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030811

InnateDB Gene

IDBG-205853 (Errfi1)

Protein Structure

UniProt Annotation

Function

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. {ECO:0000269PubMed:16648858, ECO:0000269PubMed:19439667, ECO:0000269PubMed:19683494, ECO:0000269PubMed:19710174, ECO:0000269PubMed:20018910}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16648858}. Cell membrane {ECO:0000269PubMed:16648858}; Peripheral membrane protein {ECO:0000269PubMed:16648858}; Cytoplasmic side {ECO:0000269PubMed:16648858}. Nucleus {ECO:0000305PubMed:16648858}. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.

Disease Associations

Tissue Specificity

Detected in lung, in airway epithelial cells and alveolar type 2 cells (at protein level). Detected in uterus stroma, luminal epithelium and glandular epithelium. {ECO:0000269PubMed:16648858, ECO:0000269PubMed:19710174}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0019901	protein kinase binding

Biological Process

GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0031953	negative regulation of protein autophosphorylation
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0043589	skin morphogenesis
GO:0045616	regulation of keratinocyte differentiation
GO:0048286	lung alveolus development
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0060426	lung vasculature development
GO:0060428	lung epithelium development