InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mcm7

Summary

InnateDB Protein

IDBP-205863.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mcm7

Protein Name

minichromosome maintenance deficient 7 (S. cerevisiae)

Synonyms

AI747533; mCDC47; Mcmd7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000505

InnateDB Gene

IDBG-205861 (Mcm7)

Protein Structure

UniProt Annotation

Function

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	107 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003697	single-stranded DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006260	DNA replication
GO:0006268	DNA unwinding involved in DNA replication
GO:0006270	DNA replication initiation
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process
GO:0042325	regulation of phosphorylation
GO:0042493	response to drug
GO:0071310	cellular response to organic substance
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0042555	MCM complex

Protein Structure and Domains

PDB ID

MGI:1298398

InterPro

IPR000523 Magnesium chelatase, ChlI subunit
IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
IPR003593 AAA+ ATPase domain
IPR008047 Mini-chromosome maintenance complex protein 4
IPR008050 DNA replication licensing factor Mcm7
IPR011704 ATPase, dynein-related, AAA domain
IPR012340 Nucleic acid-binding, OB-fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01078
PF00493
PF07728

PRINTS

PR01657
PR01660
PR01663

PIRSF

SMART

SM00350
SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt