InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2L3

Summary

InnateDB Protein

IDBP-2061.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2L3

Protein Name

ubiquitin-conjugating enzyme E2L 3

Synonyms

E2-F1; L-UBC; UBCH7; UbcM4;

Species

Homo sapiens

Ensembl Protein

ENSP00000344259

InnateDB Gene

IDBG-2059 (UBE2L3)

Protein Structure

UniProt Annotation

Function

Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. {ECO:0000269PubMed:10888878, ECO:0000269PubMed:15367689, ECO:0000269PubMed:17003263, ECO:0000269PubMed:18946090, ECO:0000269PubMed:19340006, ECO:0000269PubMed:20061386, ECO:0000269PubMed:21532592}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous, with highest expression in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	128 [view]
Protein-Protein	128 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006464	cellular protein modification process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008283	cell proliferation
GO:0015031	protein transport
GO:0016567	protein ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0071383	cellular response to steroid hormone stimulus
GO:0071385	cellular response to glucocorticoid stimulus

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000608 Ubiquitin-conjugating enzyme, E2
IPR006575 RWD domain
IPR008883 Ubiquitin E2 variant, N-terminal
IPR016135 Ubiquitin-conjugating enzyme/RWD-like

PFAM

PF00179
PF05773
PF05743

PRINTS

PIRSF

SMART

SM00591

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P68036