InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FNTA

Summary

InnateDB Protein

IDBP-20618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FNTA

Protein Name

farnesyltransferase, CAAX box, alpha

Synonyms

FPTA; PGGT1A; PTAR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000303423

InnateDB Gene

IDBG-20616 (FNTA)

Protein Structure

UniProt Annotation

Function

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269PubMed:12036349, ECO:0000269PubMed:12825937, ECO:0000269PubMed:16893176, ECO:0000269PubMed:19246009, ECO:0000269PubMed:8419339, ECO:0000269PubMed:8494894}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004660	protein farnesyltransferase activity
GO:0004661	protein geranylgeranyltransferase activity
GO:0004662	CAAX-protein geranylgeranyltransferase activity
GO:0004663	Rab geranylgeranyltransferase activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008318	protein prenyltransferase activity
GO:0030548	acetylcholine receptor regulator activity
GO:0030971	receptor tyrosine kinase binding
GO:0043014	alpha-tubulin binding

Biological Process

GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007603	phototransduction, visible light
GO:0010469	regulation of receptor activity
GO:0016056	rhodopsin mediated signaling pathway
GO:0018342	protein prenylation
GO:0018343	protein farnesylation
GO:0018344	protein geranylgeranylation
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0045213	neurotransmitter receptor metabolic process
GO:0090044	positive regulation of tubulin deacetylation
GO:0090045	positive regulation of deacetylase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005875	microtubule associated complex
GO:0005953	CAAX-protein geranylgeranyltransferase complex
GO:0005965	protein farnesyltransferase complex