InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spna1

Summary

InnateDB Protein

IDBP-206189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spna1

Protein Name

spectrin alpha 1

Synonyms

AF093576; AI451697; ha; ihj; nmf4; sph; Spna-1; Spna1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027817

InnateDB Gene

IDBG-206187 (Spna1)

Protein Structure

UniProt Annotation

Function

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002260	lymphocyte homeostasis
GO:0006779	porphyrin-containing compound biosynthetic process
GO:0007009	plasma membrane organization
GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0030097	hemopoiesis
GO:0032092	positive regulation of protein binding
GO:0042102	positive regulation of T cell proliferation
GO:0051693	actin filament capping

Cellular Component

GO:0008091	spectrin
GO:0014731	spectrin-associated cytoskeleton
GO:0016020	membrane
GO:0030863	cortical cytoskeleton
GO:0032437	cuticular plate

Protein Structure and Domains

PDB ID

MGI:98385

InterPro

IPR001452 SH3 domain
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain
IPR013315 Spectrin alpha chain, SH3 domain
IPR014837 EF-hand, Ca insensitive
IPR018159 Spectrin/alpha-actinin

PFAM