InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nop56

Summary

InnateDB Protein

IDBP-206244.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nop56

Protein Name

NOP56 ribonucleoprotein homolog (yeast)

Synonyms

2310044F10Rik; Nol5a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099487

InnateDB Gene

IDBG-206242 (Nop56)

Protein Structure

UniProt Annotation

Function

Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:21683323}. Nucleus, nucleoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in the central nervous system (CNS), including cerebral cortex and cerebellum, and spleen. In the CNS, expressed in Purkinje cells of the cerebellum, as well as in motor neurons of the hypoglossal nucleus and in the spinal cord anterior horn (at protein level). {ECO:0000269PubMed:21683323}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	104 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030515	snoRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0008150	biological_process
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005732	small nucleolar ribonucleoprotein complex
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070761	pre-snoRNP complex