InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ESM1

Summary

InnateDB Protein

IDBP-20699.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESM1

Protein Name

endothelial cell-specific molecule 1

Synonyms

endocan;

Species

Homo sapiens

Ensembl Protein

ENSP00000370810

InnateDB Gene

IDBG-20693 (ESM1)

Protein Structure

UniProt Annotation

Function

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions. {ECO:0000269PubMed:20616313}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005171	hepatocyte growth factor receptor binding
GO:0005178	integrin binding
GO:0005520	insulin-like growth factor binding

Biological Process

GO:0001525	angiogenesis
GO:0001558	regulation of cell growth
GO:0002040	sprouting angiogenesis
GO:0008284	positive regulation of cell proliferation
GO:1902204	positive regulation of hepatocyte growth factor receptor signaling pathway