InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmp2

Summary

InnateDB Protein

IDBP-207602.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmp2

Protein Name

bone morphogenetic protein 2

Synonyms

AI467020; Bmp2a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028836

InnateDB Gene

IDBG-207600 (Bmp2)

Protein Structure

UniProt Annotation

Function

Induces cartilage and bone formation.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004745	retinol dehydrogenase activity
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0019211	phosphatase activator activity
GO:0046332	SMAD binding
GO:0046982	protein heterodimerization activity
GO:0070700	BMP receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000187	activation of MAPK activity
GO:0001649	osteoblast differentiation
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001837	epithelial to mesenchymal transition
GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002062	chondrocyte differentiation
GO:0003130	BMP signaling pathway involved in heart induction
GO:0003181	atrioventricular valve morphogenesis
GO:0003203	endocardial cushion morphogenesis
GO:0003308	negative regulation of Wnt receptor signaling pathway involved in heart development
GO:0006029	proteoglycan metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010894	negative regulation of steroid biosynthetic process
GO:0010922	positive regulation of phosphatase activity
GO:0021537	telencephalon development
GO:0021978	telencephalon regionalization
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030282	bone mineralization
GO:0030335	positive regulation of cell migration
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0031648	protein destabilization
GO:0032348	negative regulation of aldosterone biosynthetic process
GO:0033690	positive regulation of osteoblast proliferation
GO:0035051	cardiac cell differentiation
GO:0035054	embryonic heart tube anterior/posterior pattern specification
GO:0035630	bone mineralization involved in bone maturation
GO:0040007	growth
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042482	positive regulation of odontogenesis
GO:0042487	regulation of odontogenesis of dentin-containing tooth
GO:0043065	positive regulation of apoptotic process
GO:0043410	positive regulation of MAPK cascade
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045165	cell fate commitment
GO:0045597	positive regulation of cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045778	positive regulation of ossification
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048711	positive regulation of astrocyte differentiation
GO:0048762	mesenchymal cell differentiation
GO:0048839	inner ear development
GO:0050769	positive regulation of neurogenesis
GO:0051042	negative regulation of calcium-independent cell-cell adhesion
GO:0055007	cardiac muscle cell differentiation
GO:0055008	cardiac muscle tissue morphogenesis
GO:0055114	oxidation-reduction process
GO:0060039	pericardium development
GO:0060128	corticotropin hormone secreting cell differentiation
GO:0060129	thyroid-stimulating hormone-secreting cell differentiation
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0060395	SMAD protein signal transduction
GO:0060485	mesenchyme development
GO:0060804	positive regulation of Wnt receptor signaling pathway by BMP signaling pathway
GO:0061036	positive regulation of cartilage development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071363	cellular response to growth factor stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071773	cellular response to BMP stimulus
GO:0072138	mesenchymal cell proliferation involved in ureteric bud development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1900745	positive regulation of p38MAPK cascade
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:2000065	negative regulation of cortisol biosynthetic process
GO:2000726	negative regulation of cardiac muscle cell differentiation