Version 5.4
Mus musculus Protein: Lamp5
Summary
InnateDB Protein IDBP-207762.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lamp5
Protein Name RIKEN cDNA 6330527O06 gene
Synonyms 3110035N03Rik; 6330527O06Rik; BAD-LAMP; LAMP-5;
Species Mus musculus
Ensembl Protein ENSMUSP00000061180
InnateDB Gene IDBG-207760 (Lamp5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasmic vesicle {ECO:0000269PubMed:17215451}. Cell membrane {ECO:0000269PubMed:17215451}; Single-pass type I membrane protein {ECO:0000269PubMed:17215451}. Cell projection, dendrite {ECO:0000269PubMed:17215451}. Cell projection, growth cone membrane {ECO:0000269PubMed:17215451}. Early endosome membrane {ECO:0000269PubMed:17215451}; Single-pass type I membrane protein {ECO:0000269PubMed:17215451}. Recycling endosome {ECO:0000269PubMed:17215451}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes (By similarity). Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the forebrain. Expressed in the cingulate cortex, cortical plate, caudate putamen. Expressed in brain. Expressed in neurons of layers II/III and V of the neocortex. {ECO:0000269PubMed:17215451}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0031901 early endosome membrane
GO:0032584 growth cone membrane
GO:0032590 dendrite membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055038 recycling endosome membrane
Protein Structure and Domains
PDB ID MGI:1923411
InterPro IPR002000 Lysosome-associated membrane glycoprotein
PFAM PF01299
PRINTS PR00336
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D387
PhosphoSite PhosphoSite-
TrEMBL A2AT95
UniProt Splice Variant
Entrez Gene 76161
UniGene Mm.489894
RefSeq NP_083806
MGI ID
MGI Symbol Lamp5
OMIM
CCDS CCDS16789
HPRD
IMGT
EMBL AK014127 AK018222 AL845354 AL928798 BC004791
GenPept AAH04791 BAB29169

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca