InnateDB Protein
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IDBP-208529.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Polr3f
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Protein Name
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polymerase (RNA) III (DNA directed) polypeptide F
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Synonyms
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2810411G20Rik; 3010019O03Rik; 3110032A07Rik; RPC39; RPC6;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000028914
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InnateDB Gene
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IDBG-208527 (Polr3f)
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Protein Structure
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Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
GO:0005666
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DNA-directed RNA polymerase III complex
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PDB ID |
MGI:1924086
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InterPro |
IPR007832
RNA polymerase Rpc34
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PFAM |
PF05158
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PRINTS |
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PIRSF |
PIRSF028763
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q921X6
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PhosphoSite |
PhosphoSite-Q921X6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
70408
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UniGene |
Mm.475761
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RefSeq |
NP_084039
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MGI ID |
2DK8
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MGI Symbol |
Polr3f
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OMIM |
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CCDS |
CCDS16820
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HPRD |
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IMGT |
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EMBL |
AK036166
AK076538
AK144679
BC009159
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GenPept |
AAH09159
BAC29327
BAC36385
BAE26008
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