InnateDB Protein
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IDBP-20921.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATF7IP
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Protein Name
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activating transcription factor 7 interacting protein
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000261168
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InnateDB Gene
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IDBG-20919 (ATF7IP)
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Protein Structure
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Function |
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells. {ECO:0000269PubMed:12665582, ECO:0000269PubMed:14536086, ECO:0000269PubMed:19106100}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:19106100}.
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Disease Associations |
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Tissue Specificity |
Detected at low levels in breast, lung and stomach; highly up-regulated in the corresponding cancerous tissues (at protein level). {ECO:0000269PubMed:19106100}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
109
[view]
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Protein-Protein |
109
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
GO:0006306
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DNA methylation
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GO:0006351
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transcription, DNA-templated
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GO:0016032
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viral process
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045898
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regulation of RNA polymerase II transcriptional preinitiation complex assembly
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Cellular Component |
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PDB ID |
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InterPro |
IPR003961
Fibronectin, type III
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PFAM |
PF00041
PF01108
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PRINTS |
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PIRSF |
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SMART |
SM00060
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TIGRFAMs |
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Modification |
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SwissProt |
Q6VMQ6
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PhosphoSite |
PhosphoSite-Q6VMQ6
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TrEMBL |
F8WE35
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UniProt Splice Variant |
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Entrez Gene |
55729
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UniGene |
Hs.742255
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RefSeq |
NP_060649
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HUGO |
HGNC:20092
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OMIM |
613644
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CCDS |
CCDS8663
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HPRD |
09811
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IMGT |
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EMBL |
AC007782
AC008114
AC008814
AC124892
AF425650
AJ242978
AK001001
AK001550
AY337596
BC037312
BC063855
CH471094
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GenPept |
AAH37312
AAH63855
AAO91864
AAQ92978
BAA91751
CAB45135
EAW96314
EAW96315
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