InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmgb1

Summary

InnateDB Protein

IDBP-209313.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmgb1

Protein Name

high mobility group box 1

Synonyms

amphoterin; DEF; HMG-1; Hmg1; p30; SBP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082682

InnateDB Gene

IDBG-209311 (Hmgb1)

Protein Structure

UniProt Annotation

Function

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. {ECO:0000269PubMed:9184213}.

Subcellular Localization

Nucleus. Cytoplasm. Chromosome. Note=Associated with the plasma membrane of filipodia in process- growing cells, and also deposited into the substrate-attached material.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	41 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008201	heparin binding
GO:0044822	poly(A) RNA binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002437	inflammatory response to antigenic stimulus
GO:0006288	base-excision repair, DNA ligation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006954	inflammatory response
GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0033151	V(D)J recombination
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388	positive regulation of DNA binding
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000426	negative regulation of apoptotic cell clearance

Cellular Component

GO:0000793	condensed chromosome
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0017053	transcriptional repressor complex