InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apobr

Summary

InnateDB Protein

IDBP-209669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apobr

Protein Name

apolipoprotein B receptor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042028

InnateDB Gene

IDBG-209667 (Apobr)

Protein Structure

UniProt Annotation

Function

Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. {ECO:0000269PubMed:12177162}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in spleen, lung and skeletal muscle, and weakly in brain, heart, kidney, and testis. {ECO:0000269PubMed:12177162}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030229	very-low-density lipoprotein particle receptor activity

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006869	lipid transport
GO:0006898	receptor-mediated endocytosis
GO:0008203	cholesterol metabolic process

Cellular Component

GO:0005575	cellular_component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle
GO:0042627	chylomicron