InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Id1

Summary

InnateDB Protein

IDBP-209846.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Id1

Protein Name

inhibitor of DNA binding 1

Synonyms

AI323524; bHLHb24; D2Wsu140e; Idb1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092019

InnateDB Gene

IDBG-209844 (Id1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. {ECO:0000269PubMed:16556596, ECO:0000269PubMed:19217292}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16516211}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:16516211}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	9 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001886	endothelial cell morphogenesis
GO:0006351	transcription, DNA-templated
GO:0007507	heart development
GO:0030509	BMP signaling pathway
GO:0031648	protein destabilization
GO:0032963	collagen metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0043408	regulation of MAPK cascade
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045668	negative regulation of osteoblast differentiation
GO:0045765	regulation of angiogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046677	response to antibiotic
GO:0060425	lung morphogenesis
GO:0060426	lung vasculature development