InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxs1

Summary

InnateDB Protein

IDBP-209925.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxs1

Protein Name

forkhead box S1

Synonyms

Fkh3; Fkhl18; FREAC10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096806

InnateDB Gene

IDBG-209923 (Foxs1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature. {ECO:0000269PubMed:18288644}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089, ECO:0000269PubMed:18288644}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001503	ossification
GO:0001568	blood vessel development
GO:0001569	patterning of blood vessels
GO:0001756	somitogenesis
GO:0001946	lymphangiogenesis
GO:0001974	blood vessel remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0008286	insulin receptor signaling pathway
GO:0030199	collagen fibril organization
GO:0035050	embryonic heart tube development
GO:0040018	positive regulation of multicellular organism growth
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046620	regulation of organ growth
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048343	paraxial mesodermal cell fate commitment
GO:0048844	artery morphogenesis
GO:0050880	regulation of blood vessel size
GO:0050885	neuromuscular process controlling balance
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060038	cardiac muscle cell proliferation