InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAP1

Summary

InnateDB Protein

IDBP-21036.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAP1

Protein Name

signal transducing adaptor family member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000265404

InnateDB Gene

IDBG-21034 (STAP1)

Protein Structure

UniProt Annotation

Function

In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. {ECO:0000269PubMed:10518561}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17936702}. Cytoplasm {ECO:0000269PubMed:17936702}. Mitochondrion {ECO:0000269PubMed:17936702}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0061025	membrane fusion