InnateDB Protein
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IDBP-210471.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Chmp4b
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Protein Name
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charged multivesicular body protein 4B
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Synonyms
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2010012F05Rik; C76846; Snf7-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000036206
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InnateDB Gene
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IDBG-210469 (Chmp4b)
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Protein Structure
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Function |
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1922858
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InterPro |
IPR005024
Snf7
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PFAM |
PF03357
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D8B3
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PhosphoSite |
PhosphoSite-Q9D8B3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
75608
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UniGene |
Mm.262480
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RefSeq |
NP_083638
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MGI ID |
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MGI Symbol |
Chmp4b
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OMIM |
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CCDS |
CCDS16938
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HPRD |
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IMGT |
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EMBL |
AK008205
AK156473
AK159193
AL929557
BC006905
BC011429
BC059279
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GenPept |
AAH06905
AAH11429
AAH59279
BAE33724
BAE34888
CAM20092
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