Homo sapiens Protein: HIST4H4 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-21049.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | HIST4H4 | ||||||||||||||||||||||
Protein Name | histone cluster 4, H4 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000350767 | ||||||||||||||||||||||
InnateDB Gene | IDBG-21047 (HIST4H4) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. Chromosome. | ||||||||||||||||||||||
Disease Associations | Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. | ||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR001951
Histone H4 IPR004823 TATA box binding protein associated factor (TAF) IPR007125 Histone core IPR009072 Histone-fold |
||||||||||||||||||||||
PFAM |
PF02969
PF00125 |
||||||||||||||||||||||
PRINTS |
PR00623
|
||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00417
SM00803 |
||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P62805 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P62805 | ||||||||||||||||||||||
TrEMBL | Q6B823 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 8370 | ||||||||||||||||||||||
UniGene | Hs.737396 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
HUGO | HGNC:20510 | ||||||||||||||||||||||
OMIM | 615069 | ||||||||||||||||||||||
CCDS | CCDS8665 | ||||||||||||||||||||||
HPRD | 13662 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB000905 AB451459 AF525682 AK311916 AK312028 AK312153 AK316561 AL021807 AL021917 AL031777 AL049822 AL353759 AL591493 AY128653 AY128654 AY128655 AY128656 AY128657 AY128658 AY128659 AY128661 AY128662 AY128663 AY128664 AY128665 AY648850 AY675271 AY675295 BC017361 BC054014 BC066248 BC066249 BC066250 BC067495 BC067496 BC067497 BC069288 BC069392 BC069467 BC069654 BC093763 BC093765 BC093969 BC111093 BC111434 BC112193 BC120939 BC128104 BC128105 BC130558 BC130560 BC143045 BC148271 CH471081 CH471087 CH471094 CR542169 CR542172 CR542180 CR542187 CR542189 M16707 M60749 X00038 X60481 X60482 X60483 X60484 X60486 X60487 X67081 X83548 Z80787 Z98744 | ||||||||||||||||||||||
GenPept | AAA52652 AAA63188 AAH17361 AAH54014 AAH66248 AAH66249 AAH66250 AAH67495 AAH67496 AAH67497 AAH69288 AAH69392 AAH69467 AAH69654 AAH93763 AAH93765 AAH93969 AAI11094 AAI11435 AAI12194 AAI20940 AAI28105 AAI28106 AAI30559 AAI30561 AAI43046 AAI48272 AAM83108 AAN01438 AAN01439 AAN01440 AAN01441 AAN01442 AAN01443 AAN01444 AAN01446 AAN01447 AAN01448 AAN01449 AAN01450 AAT68253 AAT78448 AAT78472 BAA19208 BAG34857 BAG34965 BAG35087 BAG38150 BAG70273 CAA16946 CAA24918 CAA43011 CAA43012 CAA43013 CAA43014 CAA43016 CAA43017 CAA47464 CAA58538 CAB02549 CAC03414 CAC03418 CAC03426 CAC03427 CAC04128 CAC69642 CAD24074 CAG46966 CAG46969 CAG46977 CAG46984 CAG46986 CAI12560 CAI12567 EAW55509 EAW55510 EAW55538 EAW55549 EAW55555 EAW55556 EAW96325 EAX03086 EAX03111 EAX03112 EAX03121 | ||||||||||||||||||||||