Version 5.4
Mus musculus Protein: Phf20
Summary
InnateDB Protein IDBP-210849.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phf20
Protein Name PHD finger protein 20
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000043138
InnateDB Gene IDBG-210845 (Phf20)
Protein Structure
UniProt Annotation
Function Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage (By similarity). Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. {ECO:0000250, ECO:0000269PubMed:22072714}.
Subcellular Localization Nucleus {ECO:0000269PubMed:22072714}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046872 metal ion binding
GO:0046972 histone acetyltransferase activity (H4-K16 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
GO:0071339 MLL1 complex
Protein Structure and Domains
PDB ID MGI:2444148
InterPro IPR001965 Zinc finger, PHD-type
IPR002999 Tudor domain
IPR007087 Zinc finger, C2H2
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
IPR022255 Protein of unknown function DUF3776
PFAM PF00567
PF00096
PF00628
PF12618
PRINTS
PIRSF
SMART SM00249
SM00333
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BLG0
PhosphoSite PhosphoSite-Q8BLG0
TrEMBL Q6PAR7
UniProt Splice Variant
Entrez Gene 228829
UniGene Mm.470432
RefSeq NP_766262
MGI ID
MGI Symbol Phf20
OMIM
CCDS CCDS38297
HPRD
IMGT
EMBL AK033017 AK038573 AK045309 AL929404 BC011337 BC060121
GenPept AAH11337 AAH60121 BAC28129 BAC30050 BAC32304

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca