InnateDB Protein
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IDBP-21109.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CINP
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Protein Name
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cyclin-dependent kinase 2 interacting protein
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000216756
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InnateDB Gene
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IDBG-21107 (CINP)
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Protein Structure
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Function |
Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. {ECO:0000269PubMed:16082200, ECO:0000269PubMed:19889979}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:19889979}. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR023250
Cyclin-dependent kinase 2-interacting protein
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PFAM |
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PRINTS |
PR02040
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BW66
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PhosphoSite |
PhosphoSite-Q9BW66
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TrEMBL |
A0A024R6M9
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UniProt Splice Variant |
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Entrez Gene |
51550
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UniGene |
Hs.736782
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RefSeq |
NP_116019
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HUGO |
HGNC:23789
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OMIM |
613362
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CCDS |
CCDS9972
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HPRD |
16715
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IMGT |
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EMBL |
AF228148
AF228149
AK056112
AL137229
BC000600
BU174070
CH471061
CR457178
DA167716
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GenPept |
AAF44747
AAF44748
AAH00600
BAB71095
CAG33459
EAW81785
EAW81786
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