InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nags

Summary

InnateDB Protein

IDBP-212465.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nags

Protein Name

N-acetylglutamate synthase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050258

InnateDB Gene

IDBG-212463 (Nags)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Highly expressed in the liver and small intestine. Weakly expressed in the kidney, spleen and testis. {ECO:0000269PubMed:12049647}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004042	acetyl-CoA:L-glutamate N-acetyltransferase activity
GO:0008080	N-acetyltransferase activity

Biological Process

GO:0000050	urea cycle
GO:0006526	arginine biosynthetic process
GO:0006536	glutamate metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:2387600

InterPro

IPR000182 GNAT domain
IPR001048 Aspartate/glutamate/uridylate kinase
IPR006855 Domain of unknown function DUF619
IPR011243 N-acetylglutamate synthase, animal
IPR016181 Acyl-CoA N-acyltransferase

PFAM