Version 5.4
Mus musculus Protein: Grn
Summary
InnateDB Protein IDBP-212644.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grn
Protein Name granulin
Synonyms epithelin; Pgrn;
Species Mus musculus
Ensembl Protein ENSMUSP00000046340
InnateDB Gene IDBG-212642 (Grn)
Protein Structure
UniProt Annotation
Function Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Acts as an autocrine growth factor for PC cells. {ECO:0000269PubMed:8496151}.
Subcellular Localization Secreted {ECO:0000269PubMed:8496151}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001835 blastocyst hatching
GO:0007566 embryo implantation
GO:0045087 innate immune response (InnateDB)
GO:0050679 positive regulation of epithelial cell proliferation
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:95832
InterPro IPR000118 Granulin
PFAM PF00396
PRINTS
PIRSF
SMART SM00277
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28798
PhosphoSite PhosphoSite-P28798
TrEMBL Q544Y8
UniProt Splice Variant
Entrez Gene 14824
UniGene Mm.1568
RefSeq NP_032201
MGI ID
MGI Symbol Grn
OMIM
CCDS CCDS48943
HPRD
IMGT
EMBL AK013678 AK150338 AK150420 AK151007 AK151713 AK151756 AK152087 AK152118 AK152213 AK152705 AK152765 AK152944 AK153289 AK153418 AK154492 AK159428 AK160033 AK160074 AL596258 BC129849 BC129850 CH466558 D16195 M86736 X62321
GenPept AAA37191 AAI29850 AAI29851 BAA03736 BAB28951 BAE29480 BAE29544 BAE30030 BAE30632 BAE30664 BAE30937 BAE30962 BAE31041 BAE31433 BAE31478 BAE31615 BAE31872 BAE31978 BAE32624 BAE35075 BAE35576 BAE35608 CAA44197 EDL34133 EDL34134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca