InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccnd1

Summary

InnateDB Protein

IDBP-212975.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccnd1

Protein Name

cyclin D1

Synonyms

AI327039; bcl-1; cD1; CycD1; Cyl-1; PRAD1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091495

InnateDB Gene

IDBG-212973 (Ccnd1)

Protein Structure

UniProt Annotation

Function

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19767775}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 117 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	44 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	117 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016301	kinase activity
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0042826	histone deacetylase binding
GO:0070064	proline-rich region binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000320	re-entry into mitotic cell cycle
GO:0001889	liver development
GO:0001934	positive regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0010033	response to organic substance
GO:0010039	response to iron ion
GO:0010165	response to X-ray
GO:0010243	response to organonitrogen compound
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0014070	response to organic cyclic compound
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031100	organ regeneration
GO:0031571	mitotic G1 DNA damage checkpoint
GO:0032026	response to magnesium ion
GO:0033197	response to vitamin E
GO:0033327	Leydig cell differentiation
GO:0033598	mammary gland epithelial cell proliferation
GO:0033601	positive regulation of mammary gland epithelial cell proliferation
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0045444	fat cell differentiation
GO:0045471	response to ethanol
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0048545	response to steroid hormone
GO:0051301	cell division
GO:0051384	response to glucocorticoid
GO:0051412	response to corticosterone
GO:0051592	response to calcium ion
GO:0051726	regulation of cell cycle
GO:0060070	canonical Wnt signaling pathway
GO:0060749	mammary gland alveolus development
GO:0070141	response to UV-A
GO:0071157	negative regulation of cell cycle arrest
GO:0071310	cellular response to organic substance
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0000307	cyclin-dependent protein kinase holoenzyme complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005923	tight junction
GO:0016020	membrane
GO:0017053	transcriptional repressor complex