Version 5.4
Mus musculus Protein: Dcaf7
Summary
InnateDB Protein IDBP-213335.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dcaf7
Protein Name DDB1 and CUL4 associated factor 7
Synonyms 1700012F10Rik; 2610037L01Rik; C86529; HAN11; Wdr68;
Species Mus musculus
Ensembl Protein ENSMUSP00000058168
InnateDB Gene IDBG-213333 (Dcaf7)
Protein Structure
UniProt Annotation
Function Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}. Nucleus {ECO:0000250}. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0043234 protein complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:1919083
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P61963
PhosphoSite PhosphoSite-P61963
TrEMBL Q80ZU1
UniProt Splice Variant
Entrez Gene 71833
UniGene Mm.307455
RefSeq NP_082222
MGI ID
MGI Symbol Dcaf7
OMIM
CCDS CCDS25546
HPRD
IMGT
EMBL AK005902 AK047435 AK165674 BC048165 BC048722
GenPept AAH48165 AAH48722 BAB24308 BAC33058 BAE38331

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca