InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGDIB

Summary

InnateDB Protein

IDBP-21366.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGDIB

Protein Name

Rho GDP dissociation inhibitor (GDI) beta

Synonyms

D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1; RhoGDI2;

Species

Homo sapiens

Ensembl Protein

ENSP00000228945

InnateDB Gene

IDBG-21364 (ARHGDIB)

Protein Structure

UniProt Annotation

Function

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005094	Rho GDP-dissociation inhibitor activity
GO:0005096	GTPase activator activity

Biological Process

GO:0006928	cellular component movement
GO:0006955	immune response
GO:0007162	negative regulation of cell adhesion
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0007275	multicellular organismal development
GO:0030036	actin cytoskeleton organization
GO:0043547	positive regulation of GTPase activity
GO:0050790	regulation of catalytic activity
GO:0051056	regulation of small GTPase mediated signal transduction