InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbx2

Summary

InnateDB Protein

IDBP-214667.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbx2

Protein Name

chromobox homolog 2 (Drosophila Pc class)

Synonyms

M33; MOD2; pc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026662

InnateDB Gene

IDBG-214665 (Cbx2)

Protein Structure

UniProt Annotation

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:9312051}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0035064	methylated histone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0016568	chromatin modification
GO:0045137	development of primary sexual characteristics