InnateDB Protein
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IDBP-214787.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fscn2
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Protein Name
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fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000026445
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InnateDB Gene
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IDBG-214785 (Fscn2)
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Protein Structure
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Function |
Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundless in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links. {ECO:0000269PubMed:20660251}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:20660251}. Cell projection, stereocilium {ECO:0000269PubMed:20660251}. Note=Found mostly in longer hair- cell stereocilia and, in all stereocilia, present in gradient with the highest concentration at stereocilia tips.
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Disease Associations |
Note=Defects in Fscn2 lead to hair-cell degeneration in the inner ear and are a key contributor to the early-onset, age- related hearing loss (prebycusis) phenotype when in combination with waltzer cadherin 23 mutant.
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Tissue Specificity |
Expressed in the inner ear.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2443337
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InterPro |
IPR002209
Fibroblast growth factor family
IPR008999
Actin cross-linking
IPR022768
Fascin domain
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PFAM |
PF06268
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PRINTS |
PR00263
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PIRSF |
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SMART |
SM00442
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TIGRFAMs |
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Modification |
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SwissProt |
Q32M02
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
238021
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UniGene |
Mm.481403
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RefSeq |
NP_766390
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MGI ID |
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MGI Symbol |
Fscn2
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OMIM |
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CCDS |
CCDS25731
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HPRD |
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IMGT |
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EMBL |
AK050002
AL669855
BC109356
BC109357
CH466558
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GenPept |
AAI09357
AAI09358
BAC34026
CAM27038
EDL34739
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