InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OPRK1

Summary

InnateDB Protein

IDBP-21601.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OPRK1

Protein Name

opioid receptor, kappa 1

Synonyms

K-OR-1; KOR; KOR-1; OPRK;

Species

Homo sapiens

Ensembl Protein

ENSP00000265572

InnateDB Gene

IDBG-21599 (OPRK1)

Protein Structure

UniProt Annotation

Function

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269PubMed:12004055, ECO:0000269PubMed:22437504, ECO:0000269PubMed:7624359, ECO:0000269PubMed:8060324}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12004055, ECO:0000269PubMed:22437504, ECO:0000269PubMed:7624359, ECO:0000269PubMed:8060324}; Multi-pass membrane protein {ECO:0000269PubMed:12004055, ECO:0000269PubMed:22437504, ECO:0000269PubMed:7624359, ECO:0000269PubMed:8060324}.

Disease Associations

Tissue Specificity

Detected in brain and placenta. {ECO:0000269PubMed:7624359, ECO:0000269PubMed:8060324}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004985	opioid receptor activity
GO:0005515	protein binding
GO:0038048	dynorphin receptor activity

Biological Process

GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007600	sensory perception
GO:0007610	behavior
GO:0007626	locomotory behavior
GO:0019233	sensory perception of pain
GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway
GO:0038003	opioid receptor signaling pathway
GO:0046877	regulation of saliva secretion
GO:0051607	defense response to virus

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000452 Kappa opioid receptor
IPR000586 Somatostatin receptor family
IPR000611 Neuropeptide Y receptor family
IPR001418 Opioid receptor
IPR009150 Neuropeptide B/W receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10323
PF10328

PRINTS

PR00237
PR00532
PR00246
PR01012
PR00384
PR01855

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P41145