InnateDB Protein
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IDBP-21690.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TNFSF9
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Protein Name
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tumor necrosis factor (ligand) superfamily, member 9
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Synonyms
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4-1BB-L; CD137L;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000245817
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InnateDB Gene
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IDBG-21688 (TNFSF9)
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Protein Structure
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Function |
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. {ECO:0000269PubMed:20032458}.
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Subcellular Localization |
Membrane; Single-pass type II membrane protein.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, placenta, lung, skeletal muscle and kidney.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
|
Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006052
Tumour necrosis factor domain
IPR008983
Tumour necrosis factor-like domain
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PFAM |
PF00229
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PRINTS |
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PIRSF |
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SMART |
SM00207
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TIGRFAMs |
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Modification |
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SwissProt |
P41273
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PhosphoSite |
PhosphoSite-P41273
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8744
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UniGene |
Hs.1524
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RefSeq |
NP_003802
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HUGO |
HGNC:11939
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OMIM |
606182
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CCDS |
CCDS12169
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HPRD |
05861
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IMGT |
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EMBL |
BC104805
BC104807
U03398
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GenPept |
AAA53134
AAI04806
AAI04808
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