InnateDB Protein
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IDBP-21790.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RGS20
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Protein Name
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regulator of G-protein signaling 20
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Synonyms
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g(z)GAP; gz-GAP; RGSZ1; ZGAP1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344630
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InnateDB Gene
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IDBG-21786 (RGS20)
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Protein Structure
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Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
32
[view]
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Protein-Protein |
32
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043547
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positive regulation of GTPase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000342
Regulator of G protein signalling domain
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
PF00615
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PRINTS |
PR01301
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
O76081
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PhosphoSite |
PhosphoSite-O76081
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TrEMBL |
B3KSW4
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UniProt Splice Variant |
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Entrez Gene |
8601
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UniGene |
Hs.741492
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RefSeq |
NP_001273602
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HUGO |
HGNC:14600
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OMIM |
607193
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CCDS |
CCDS69482
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HPRD |
06225
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IMGT |
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EMBL |
AC100821
AC113194
AF060877
AF074979
AF366054
AF366055
AF366056
AF366057
AF493940
AK094503
AY046538
BC015614
BC063490
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GenPept |
AAC62009
AAC62013
AAH15614
AAH63490
AAK54122
AAK54123
AAK54124
AAK54125
AAL03971
AAM12654
BAG52876
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